Radiation therapy impairs endothelium-dependent vasodilation in humans
Identifieur interne : 009D64 ( Main/Exploration ); précédent : 009D63; suivant : 009D65Radiation therapy impairs endothelium-dependent vasodilation in humans
Auteurs : Joshua A. Beckman [États-Unis] ; Avni Thakore [États-Unis] ; Barbara H. Kalinowski [États-Unis] ; Jay R. Harris [États-Unis] ; Mark A. Creager [États-Unis]Source :
- Journal of the American College of Cardiology [ 0735-1097 ] ; 2001.
English descriptors
Abstract
OBJECTIVESThe objective of this study was to test the hypothesis that external-beam radiation induces a chronic impairment of endothelium-dependent vasodilation.BACKGROUNDRadiation therapy is used commonly in the treatment of cancer and is associated with an increased incidence of adverse vascular events related to the field of radiation, including stroke and myocardial infarction. As endothelial injury is central to the pathogenesis of vascular diseases, we hypothesized that radiotherapy induces arterial endothelial dysfunction.METHODSSixteen women with unilateral breast cancer who underwent standard external-beam radiation therapy to the breast and axilla >3 years before enrollment and ten healthy women were studied. Vascular ultrasonography was used to image both the artery exposed to radiation and the contralateral artery. Flow-mediated, endothelium-dependent vasodilation and endothelium-independent vasodilation to nitroglycerin of both axillary arteries were measured.RESULTSEndothelium-dependent vasodilation was significantly impaired in the irradiated axillary arteries compared with the contralateral, nonirradiated arteries (−0.4 ± 0.4% vs. 3.2 ± 0.8%, p < 0.001) and also compared with control subjects’ arteries (−0.4 ± 0.4% vs. 2.5 ± 0.6%, p < 0.001). In contrast, endothelium-independent vasodilation was greater in the arteries that received radiation compared with the contralateral arteries (3.8 ± 0.5% vs. 2.0 ± 0.4%, p < 0.05) and also compared with control arteries (3.8 ± 0.5% vs. 2.5 ± 0.4%, p < 0.05).CONCLUSIONSExternal beam radiation therapy impairs endothelium-dependent vasodilation of conduit arteries, implicating a decrease in the bioavailability of nitric oxide. These abnormalities may contribute to the development of arterial occlusive disease and associated clinical events.
Url:
DOI: 10.1016/S0735-1097(00)01190-6
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 006D31
- to stream Istex, to step Curation: 006D31
- to stream Istex, to step Checkpoint: 002A66
- to stream Main, to step Merge: 00A216
- to stream Main, to step Curation: 009D64
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Radiation therapy impairs endothelium-dependent vasodilation in humans</title><author><name sortKey="Beckman, Joshua A" sort="Beckman, Joshua A" uniqKey="Beckman J" first="Joshua A" last="Beckman">Joshua A. Beckman</name></author><author><name sortKey="Thakore, Avni" sort="Thakore, Avni" uniqKey="Thakore A" first="Avni" last="Thakore">Avni Thakore</name></author><author><name sortKey="Kalinowski, Barbara H" sort="Kalinowski, Barbara H" uniqKey="Kalinowski B" first="Barbara H" last="Kalinowski">Barbara H. Kalinowski</name></author><author><name sortKey="Harris, Jay R" sort="Harris, Jay R" uniqKey="Harris J" first="Jay R" last="Harris">Jay R. Harris</name></author><author><name sortKey="Creager, Mark A" sort="Creager, Mark A" uniqKey="Creager M" first="Mark A" last="Creager">Mark A. Creager</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E8FBCAAB71401269CBDBA928BA64E4206BF9E5F0</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1016/S0735-1097(00)01190-6</idno><idno type="url">https://api.istex.fr/document/E8FBCAAB71401269CBDBA928BA64E4206BF9E5F0/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">006D31</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">006D31</idno><idno type="wicri:Area/Istex/Curation">006D31</idno><idno type="wicri:Area/Istex/Checkpoint">002A66</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002A66</idno><idno type="wicri:doubleKey">0735-1097:2001:Beckman J:radiation:therapy:impairs</idno><idno type="wicri:Area/Main/Merge">00A216</idno><idno type="wicri:Area/Main/Curation">009D64</idno><idno type="wicri:Area/Main/Exploration">009D64</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Radiation therapy impairs endothelium-dependent vasodilation in humans</title><author><name sortKey="Beckman, Joshua A" sort="Beckman, Joshua A" uniqKey="Beckman J" first="Joshua A" last="Beckman">Joshua A. Beckman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vascular Medicine Section, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Thakore, Avni" sort="Thakore, Avni" uniqKey="Thakore A" first="Avni" last="Thakore">Avni Thakore</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vascular Medicine Section, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kalinowski, Barbara H" sort="Kalinowski, Barbara H" uniqKey="Kalinowski B" first="Barbara H" last="Kalinowski">Barbara H. Kalinowski</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Harris, Jay R" sort="Harris, Jay R" uniqKey="Harris J" first="Jay R" last="Harris">Jay R. Harris</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Creager, Mark A" sort="Creager, Mark A" uniqKey="Creager M" first="Mark A" last="Creager">Mark A. Creager</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Vascular Medicine Section, Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Reprint requests and correspondence: Dr. Mark A. Creager, Cardiovascular Division, Brigham and Women’s Hospital, 75 Francis Street, Boston</wicri:cityArea></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the American College of Cardiology</title><title level="j" type="abbrev">JAC</title><idno type="ISSN">0735-1097</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2001">2001</date><biblScope unit="volume">37</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="761">761</biblScope><biblScope unit="page" to="765">765</biblScope></imprint><idno type="ISSN">0735-1097</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0735-1097</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>BP</term><term>LDL</term><term>MI</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVESThe objective of this study was to test the hypothesis that external-beam radiation induces a chronic impairment of endothelium-dependent vasodilation.BACKGROUNDRadiation therapy is used commonly in the treatment of cancer and is associated with an increased incidence of adverse vascular events related to the field of radiation, including stroke and myocardial infarction. As endothelial injury is central to the pathogenesis of vascular diseases, we hypothesized that radiotherapy induces arterial endothelial dysfunction.METHODSSixteen women with unilateral breast cancer who underwent standard external-beam radiation therapy to the breast and axilla >3 years before enrollment and ten healthy women were studied. Vascular ultrasonography was used to image both the artery exposed to radiation and the contralateral artery. Flow-mediated, endothelium-dependent vasodilation and endothelium-independent vasodilation to nitroglycerin of both axillary arteries were measured.RESULTSEndothelium-dependent vasodilation was significantly impaired in the irradiated axillary arteries compared with the contralateral, nonirradiated arteries (−0.4 ± 0.4% vs. 3.2 ± 0.8%, p < 0.001) and also compared with control subjects’ arteries (−0.4 ± 0.4% vs. 2.5 ± 0.6%, p < 0.001). In contrast, endothelium-independent vasodilation was greater in the arteries that received radiation compared with the contralateral arteries (3.8 ± 0.5% vs. 2.0 ± 0.4%, p < 0.05) and also compared with control arteries (3.8 ± 0.5% vs. 2.5 ± 0.4%, p < 0.05).CONCLUSIONSExternal beam radiation therapy impairs endothelium-dependent vasodilation of conduit arteries, implicating a decrease in the bioavailability of nitric oxide. These abnormalities may contribute to the development of arterial occlusive disease and associated clinical events.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li></region></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Beckman, Joshua A" sort="Beckman, Joshua A" uniqKey="Beckman J" first="Joshua A" last="Beckman">Joshua A. Beckman</name></region><name sortKey="Creager, Mark A" sort="Creager, Mark A" uniqKey="Creager M" first="Mark A" last="Creager">Mark A. Creager</name><name sortKey="Creager, Mark A" sort="Creager, Mark A" uniqKey="Creager M" first="Mark A" last="Creager">Mark A. Creager</name><name sortKey="Harris, Jay R" sort="Harris, Jay R" uniqKey="Harris J" first="Jay R" last="Harris">Jay R. Harris</name><name sortKey="Kalinowski, Barbara H" sort="Kalinowski, Barbara H" uniqKey="Kalinowski B" first="Barbara H" last="Kalinowski">Barbara H. Kalinowski</name><name sortKey="Thakore, Avni" sort="Thakore, Avni" uniqKey="Thakore A" first="Avni" last="Thakore">Avni Thakore</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 009D64 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 009D64 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E8FBCAAB71401269CBDBA928BA64E4206BF9E5F0
|texte= Radiation therapy impairs endothelium-dependent vasodilation in humans
}}
| This area was generated with Dilib version V0.6.31. |  |